BMSC207 Lecture Notes - Lecture 13: Papillomaviridae, Subclinical Infection, Gardasil
Virology
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intro & HPV:
No, they need a host to replicate, so they won't be the first
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they are parasites
○
Do you think the virus (structurally the simplest ‘organism’) was the first ‘livi ng being’? Why?
The common cold is always mutating (over 100 types of rhi novirus) so an efficient vaccine
be made against it. The RNA viruses are
○
Why do some vaccines such as polio, last you a lifetime, whilst there is no effective vaccine against
common cold?
Warts, cervical cancer
Coldsore (HSV1), genital warts (HSV2)
Chicken pox, shingles
Diarrhoea, vomiting
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enterovirus
Hepatitis
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liver inflammation
Common cold
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only upper respiratory
Flu (A, B and C)
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upper and lower respiratory
Haemorrhagic fever
Immunocompromised (AIDS)
Classification of viruses:
Shared 1975 Nobel Prize for Physiology or Medicine
David Baltimore, Howard Temin, and Renato Dulbecco discovered retroviruses and reverse
transcriptase
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The baltimore classification:
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DNA or RNA
Nucleic acid
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Single or double stranded
Strandedness
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Can effect ribosomes and affect protein synthesis
Sense○
Method of replication○
Baltimore developed classification scheme for viruses based on relationship of viral genome to its •
Virus structure overview:
Encodes for the transcription of all viral protein components, such as structural proteins and
enzymes (such as RNA/DNA polymerase or virus evasion molecules)
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Nucleic acid core (genetic material)•
Protective coating made of viral proteins
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Capsid•
Not all viruses have envelopes
Surrounds capsid, derived from cellular membrane (eg. PM, ER)
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Attachment to host
Membrane fusion
Contain viral glycoproteins
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Envelopes•
Virus lifecycle in outline:
Characters by a single step growth curve:
Eclipse ○
maturation
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Latent period:
•
Virus is replication
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Cell does not appear to be infected, but is○
Eclipse•
Virus is being assembled
Maturation:
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Lecture 7 - 12/9/16
Monday, 12 September 2016
10:02 AM
Lectures Page 1
Document Summary
No, they need a host to replicate, so they won"t be the first - they are parasites. The common cold is always mutating (over 100 types of rhi novi rus) so an efficient vaccine be made against it. Flu (a, b and c) - upper and lower respiratory. David baltimore, howard temin, and renato dulbecco discovered retroviruses and reverse transcriptase. Shared 1975 nobel prize for physiology or medicine. Baltimore developed classification scheme for viruses based on relationship of viral genome to its. Can effect ribosomes and affect protein synthesi s. Encodes for the transcri ption of al l viral protein components, such as structural proteins and enzymes (such as rna/dna polymerase or virus evasion molecules) Surrounds capsi d, derived from cellular membrane (eg. pm, er) Cell does not appear to be infected, but is. Often necessary for replication of virus nucleic acid. Early proteins may also be involved in immune evasion strategies.
