PHTY303 Lecture Notes - Lecture 1: Central Nervous System, Multiple Sclerosis, Disabilities Affecting Intellectual Abilities
Document Summary
On completion of this lesson you will be able to: describe multiple sclerosis in terms of its. Ms is an autoimmune system mediated, chronic inflammatory demyelinating disease of the central nervous system (cns) (sibley, 1985). The cause of ms is uncertain: immunopathology (hunter & rodrigez 1995) develops in a genetically susceptible individual (bell & lathrop, 1996) exposed to an environmental trigger (sibley et al, 1985). Inflammatory processes cause oedema and the autoimmune response causes immune t cells to strip the axon of myelin. Demyelinated areas have partial or full demyelination causing nerve conduction to be partially or fully blocked. Axonal loss has been suggested to be a main contributor to brain atrophy observed on mri and has been linked to physical and cognitive disability (zivadinov et al, Brain atrophy has also been cited as a possible predictor of disease progression in.
