BIOL2174 Lecture Notes - Lecture 9: Glucose Transporter, Glut1, Hexose
Document Summary
Transport glucose and related hexoses via a ping-pong (alternating conformation) mechanism. There are 14 members of the glut family expressed in humans. Many play a specific role in glucose metabolism determined by their pattern of tissue expression, substrate specificity, transport kinetics, and regulated expression in different physiological conditions. The primary physiological substrate for at least some of the glut transporters is unknown. Members of the family play a role in glucose uptake in other organisms. Glut1 = glucose transporter in red blood cells. Sits on blood-brain barrier and transports glucose across epithelial cells from. Sits on blood-brain barrier and transports glucose across epithelial cells from blood to brain so neurons have access to energy. Preincubated blood solution with radioactive glucose - easy to see/trace. Red blood cells then take up the radioactive glucose. The eternal solution was then washed away, and cells were places in a non- radioactive solution.
