BM1022 Lecture Notes - Lecture 35: Cholinergic, Nicotinic Acetylcholine Receptor, Catechol-O-Methyl Transferase
Document Summary
Link the role of acetylcholine in the peripheral nervous system with end organ effects. Predict the effects of drugs that block and mimic acetylcholine at various end organs. Neurotransmitter released from both the parasympathetic and sympathetic nervous system. Post ganglionic parasympathetic nerve fibers (muscarinic ach receptors (machr. Post ganglionic sympathetic nerve fibers (sweat glands only (machr)). Brain, adrenal medulla, parasympathetic and sympathetic ganglia, peripheral neuron, skeletal muscle. Smooth muscle, cardiac muscle and glands, brain, hypothalamus. M4 and m5 - not targets for drugs. us. M4 and m5 - not targets for drugs. Post ganglionic sympathetic nerve innervation also releases the catecholamines noradrenaline. Catechol-o-methyltransferase (comt) - circulating na and adrenaline -liver, kidneys, gi tract. These drugs bind to muscarinic receptors and mimic the actin of acetylcholine on the parasympathetic nervous system: Simulate effect at the ganglia, adrenal medulla and skeletal muscle. Stimulate effect at post ganglionic nerve endings in cardiac muscle, smoot muscle and glands.
