BIOL10003 Lecture 9: Evolution of Resistance
21 Jul 2018
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First part: why sickle cell anaemia is more common in malaria areas, due to natural selection of humans. Mutation: change in a gene - new allele. Homozygote: alleles from father and mother are the same. Polygenic variation: many genes combine to determine a characteristic (or "trait") Stroke, kidney failure, pneumonia, osteomyelitis, bone deformity, gallstones, jaundice, heart failure. If have hbs/hbs genes, usually die at birth. If a heterozygous sickle cell parent hbs/hba, and a homozygous normal parent hba/hba have a baby. Of 4 possibilities for the baby, 2 are hba/hba, 2 are hbs/hba. Of 4 possibilities, 1 is hba/hba, 2 are hbs/hba and 1 is hbs/hbs and dies before reproducing. Hbs/hba babies will also survive and reproduce less. If one parent is hbs/hba, and one parent is hba/hba. Of 4 possibilities for the baby, 2 are hba, 2 are hbs/hba. The hba/hba are likely to die, the hbs/hba may survive malaria.
