BIOM20001 Lecture Notes - Lecture 64: Blood Vessel, Zebrafish, Collagen
Document Summary
Regeneration occurs following most injury - resection or cell death (necrosis or apoptosis) e. g. can surgically removal (60%). If you remove a lobe the remaining lobes proliferate to replace it. Liver regeneration after resection in zebra fish partial hepatectomy. Compensatory growth mechanisms regulated by bmp and fgf signalling mediate. Compensatory growth mechanisms regulated by bmp and fgf signalling mediate liver regeneration in zebrafish after partial hepatectomy. Here zebra fish has 3 lobes in the liver. After removing lobes, the liver regenerates over time. Injury that ablates structure and function (infection and inflammation) incomplete regeneration. Repair by replacement of non-regenerated tissue with connective tissue +/- regeneration and scar formation. For severe or chronic tissue injury, where the underlying structure of the tissue is lost. Non dividing cells e. g. coagulative necrosis following mi. Proliferating fibroblasts (a labile cell population): produces ecm. Formation of new blood vessels - angiogenesis (neovascularisation) Provides extra blood supply and brings fibroblasts (collateral circulation) to site of injury.
