PHRM30002 Lecture Notes - Lecture 4: Mesolimbic Pathway, Catechol-O-Methyl Transferase, Carbidopa
13 Sep 2018
School
Department
Course
Professor
Document Summary
Da as precursor of na at the periphery. Da as a nt in cns: release. Post junctional: downstream effects: neuronal uptake eg. cocaine, as neuronal uptake inhibitor (lower conc & increased conc. In synapse: as drug addiction, as first sodium channel blockers (increased conc. ) (example of drug has more than one action, effect: local anesthesia & increase bp. Inactivation: neuronal uptake (pre-synaptic, metabolism, mao = monoamine oxidase (pre and post-synaptic, comt = catechol-o-methyltransferase (post-synaptic, pre-synaptic = neuronal uptake, post-synaptic extraneuronal uptake. Not all of them are targets (1) drugs as tools to understand physiology and pathology (2) drugs as therapeutics. Location of neuron decides: what enzyme they contain. In other words, end up with which product in the synthesis pathway. Da, na and adr are all catecholamines (due to structure) -methyldopa may be used to treat hypertension: can cause drowsiness and exacerbate depression, replace role of l-dopa.
