PHYS30005 Lecture Notes - Lecture 25: Immunosuppression, Cd133, Cell Therapy
25 Jul 2018
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Document Summary
Normal post-natal growth (birth adult) is mediated by fibres getting bigger (not myogenesis = hypertrophy) But muscles can be damaged: myopathies (dystrophy, trauma (burns, lacerations, crushing, exercise (classic example = weight training) Post-natal myogenesis follows a similar path to that of embryonic myogenesis. Muscle regeneration/repair is mediated by a population of resident adult stem cells termed (cid:858)satellite (cid:272)ells(cid:859) Resident population of adult stem cells present in skeletal muscles. Quiescent cell population capable of synthesizing muscle (outside cell cycle, but primed to be responsive to injury) Distinct from myonuclei reside between the plasma membrane and the basal lamina (aka muscle-stem cell niche) small dot, not big splodges. Li(cid:374)eage is (cid:374)egati(cid:448)e (do(cid:374)(cid:859)t e(cid:454)press (cid:373)ature (cid:373)us(cid:272)le, hematopoietic or endothelial cell markers) myod-, cd45-, Express pax7, pax3, cd34 = what defines them as muscle precursor/stem cells. Defined anatomical location between the muscle fibre and the basal lamina. Localised close to blood vessels easy communication/trafficking.
