BMS2021 Lecture 9: BMS2021 WEEK 9 TOPIC E
15 Aug 2018
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Define key terms used in developmental biology: cell fate specification, commitment, determination. The study of how organisms grow and develop. Modern developmental biology is a synthesis of three key areas: embryology (embryos, cytology (cells) and histology (tissues, genetics. Overall aim of developmental biology: to understand the genetic cellular mechanisms that produce a complex multi-cellular organism from a single cell. Why study developmental biology: understanding, diagnosing and treating developmental disorders (congenital birth defects, knowledge derived from developmental biology informs out understanding and treatment of cancers and other adult diseases, understanding cell differentiation cell-based therapies for human diseases: One cell many cells organised cells tissues organs. Arises through: cell proliferation, cell migration, changes in cell shape and size, cell differentiation, cell interaction (other cells, and also extra-cellular matrix ecm) Two major cell types in early developing embryo: Tightly connected to each other in sheets or tubes (cell-cell junctions) Cell fate: the developmental destination of a cell if left undisturbed in the embryo.
