IMM2011 Lecture Notes - Lecture 5: Opsonin, Interleukin-1 Family, Blood Vessel
23 Jun 2018
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LECTURE 5:IMMUNE CELL MIGRATION AND COMMUNICATION
(CYTOKINES)
Learning objecitve 1: Define cytokines and chemokines in the
context of immunity
- Cytokines are small soluble protein involved in activating immune
and inflammatory response.
- These are secreted in response to microbes by dc ,macrophages
and mast cells as well as other immune cells.
Chemokines: chemoattractant cytokines which play a role in promoting
and regulating leukocyte migration.
LO2: List the three general avenues in which cytokines interact
with their target cells and provide examples of the two most
common avenues of interactions •
- Cytokines can interact in an autocrine , paracrine and endocrine
- - however since a high concentrated of cytokine is needed to
cause activation it tends to be involved in autocrine (acts on
nearby cells) and paracrine (acts on itself) manner in normal
circumstances.
- Although endocrine actions can be seen when dc and marophages
release enough cytokines to be active distance from the site of
secretion .
- Cytokines bind to high affinity receptors on target cells it results in
signal transduction and gene transcription
- Leading to migration, activation , differentiation , proliferation and
survival
LO 3: Explain the actions of TNF, IL-1, IL-12, IFNγ and chemokines
Tumor necrosis factor (TNF)-
- It is released macrophages , t cell and mast cells .
- The biological effect is that it acts on the endothelial cells it causes
activation of inflammation and coagulation. It can cause activation
of neutrophil
Document Summary
Learning objecitve 1: define cytokines and chemokines in the context of immunity. Cytokines are small soluble protein involved in activating immune and inflammatory response. These are secreted in response to microbes by dc ,macrophages and mast cells as well as other immune cells. Chemokines: chemoattractant cytokines which play a role in promoting and regulating leukocyte migration. Lo2: list the three general avenues in which cytokines interact with their target cells and provide examples of the two most common avenues of interactions . Cytokines can interact in an autocrine , paracrine and endocrine. However since a high concentrated of cytokine is needed to cause activation it tends to be involved in autocrine (acts on nearby cells) and paracrine (acts on itself) manner in normal circumstances. Although endocrine actions can be seen when dc and marophages release enough cytokines to be active distance from the site of secretion .
