PHA3801 Lecture Notes - Lecture 10: Exponential Decay, Intravenous Therapy, Sodium Thiopental
24 Jul 2018
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Document Summary
Applied pharmacokinetics: mathematical modeling to characterize the concentration of the drug in the blood vs time after dose. Optimise treatment according to the characteristics of the drug. Optimise treatment according to disease factors in individual patients. For many drugs, disappearance from the plasma follows an exponential time-course characterized by the plasma life (3). Zero order: rate of removal constant (e. g. alcohol) Decrease in drug levels in the body that is independent of the plasma concentration, and the rat is constant by a limiting factor, such as a co-factor of enzyme availability. When the plasma concentration is placed vs time, the decrease is a straight line (2). First order: rate of removal proportional to plasma concentration of drug (most drugs). Decrease in drug level in the body is dependent on plasma concentration, as the concentration of the substrate (drug) is the rate limiting factor. When the plasma concentration is plotted vs time, the decrease is exponential (2).
