PHA2022 Lecture Notes - Lecture 10: High-Throughput Screening, Iron-Deficiency Anemia, Pharmaceutical Drug

• School: Monash University
• Department: Science - Pharmacology
• Course: PHA2022
• Professor: Elizabeth Davis

Document Summary

Dd: describe the time and financial costs involved in developing new drugs. Ans: f(cid:396)o(cid:373) a (cid:272)o(cid:373)pa(cid:374)(cid:455)(cid:859)s pe(cid:396)spe(cid:272)ti(cid:448)e, i(cid:374)(cid:272)o(cid:373)e f(cid:396)o(cid:373) (cid:373)a(cid:396)keted d(cid:396)ugs is (cid:374)eeded to fu(cid:374)d de(cid:448)elop(cid:373)e(cid:374)t (cid:858)pipeli(cid:374)e(cid:859). Esti(cid:373)ates a(cid:396)e that o(cid:374)l(cid:455) 3 i(cid:374) (cid:1005)(cid:1004) (cid:271)(cid:396)i(cid:374)g i(cid:374) e(cid:374)ough (cid:396)e(cid:448)e(cid:374)ue to (cid:272)o(cid:448)e(cid:396) (cid:272)ost of de(cid:448)elop(cid:373)e(cid:374)t. fe(cid:449) a(cid:396)e (cid:862)(cid:271)lo(cid:272)k(cid:271)uste(cid:396)s(cid:863) a(cid:374)d generate annual sales of > billion. A blockbuster drug is one that achieves acceptance by prescribing physicians as a therapeutic standard for, most commonly, a highly prevalent chronic (rather than acute) condition. Patients often take the medicines for long periods. Identify the steps involved in taking a drug from discovery to the market place. Ans: discuss how therapeutic targets are decided on. Ans: discovery: target is selected and validated > hits are screened for > limited opsonization(leads) > Success is dependent on screening systems: define terms associated with the drug development process including: hit; lead; generic; bioequivalence; biosimilar.