PHY3171 Lecture 10: L10 kidneys long term BP regulation 2
10 Feb 2019
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L9: role of the kidneys in the long-term regulation of bp. Ap salt + water excretion. During head out-out water immersion, there is a decrease in sympathetic nerve activity. Going from a low to high sodium diet. Accumulation of salt + water in body leads to increase in ap. But also leads to inhibition of rsna. Inhibition of ra system + activation of anp. Therefore, after a few weeks of high salt, blood pressure will only have increased slightly. Shifts the curve to become steeper. Caused by atherosclerosis in the renal artery or in aorta. Get an increase in renin: retain salt + water. Tpr in established hypertension but not co. Increased ap leads to autoregulatory response of vasoconstriction: vasoconstriction maintains increase in ap, and allows normalisation of co, tpr starts to increase, blood volume + ecf are also normalised. Autoregulation here is not a quick process occurs over time.
