LQB186 Lecture Notes - Lecture 12: Apaf1, Cell Membrane, Apoptosis
9 Aug 2018
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Document Summary
Causes of cell death: damage to membranes, proteins, mitochondria, lysosomes. By inappropriate enzyme activity, activation of proteins that stimulate apoptosis. The death of a cell may occur by one of two main mechanisms necrosis or apoptosis: while necrosis is a traumatic cellular response that is detrimental, apoptosis is an important and necessary cellular process. Necrosis u(cid:374)co(cid:374)trolled cell death (cid:894)(cid:858)cell ho(cid:373)icide(cid:859)(cid:895: necrosis is the premature death of a cell. Caused by disruption to the cell by injury, toxins or nutritional deprivation: the cell loses functional control there is destabilisation of the plasma and organelle membranes. Leading to swelling of the cell and organelles due to increased osmotic pressure. The cell eventually bursts: the uncontrolled release of cell contents causes inflammation, damaging surrounding tissue. Apoptosis progra(cid:373)(cid:373)ed cell death (cid:894)(cid:858)cell suicide(cid:859)(cid:895: apoptosis is a controlled event regulated by molecular signals which inhibit or promote this process. Mitochondrial proteins play an important role in initiating apoptotic processes.
