BIOC2000 Lecture Notes - Lecture 34: Acetyl-Coa, Cytochrome C Oxidase, Atp Synthase
Monday, 28 May, 2018
Glucose 03
ETC
Complex I II III IV V
NADH Dehydrogenase transfer 2e- to ubiquinnons (Cofactor embedded in ETC bilayer)
U accept 2e- and transport to Complex III Bc complex
U either accept protons from FADH2 (H+) or e- and pass e- to complex II C proteins
C lies outside the membrane and each time transfer 4e- to Complex IV (cytochrome
oxidase) binding 2 O2 and 2P to form H2O
Protons needed F1/Fo ATPase to pump H+ back to matrux (Complex V)
lack O2
-Complex IV cannot work
-ETC stops working
-Build up of NADH
-use in other pathway
-cell death
2 Shuttles to transfer e- across membrane
glycerophosphate shuttle
DHAP to G3P
shuttle is irreversible
transfer e- only to U without pumping protons
yield 2ATP synthesis
-acetyl CoA yield
-CAC oxidise carbon by loss Co2
-yield ATP
-bunch of electron
-NADH and FADH2 formation
1
Document Summary
Nadh dehydrogenase transfer 2e- to ubiquinnons (cofactor embedded in etc bilayer) U accept 2e- and transport to complex iii bc complex. U either accept protons from fadh2 (h+) or e- and pass e- to complex ii c proteins. C lies outside the membrane and each time transfer 4e- to complex iv (cytochrome oxidase) binding 2 o2 and 2p to form h2o. Protons needed f1/fo atpase to pump h+ back to matrux (complex v) lack o2. 2 shuttles to transfer e- across membrane glycerophosphate shuttle. Dhap to g3p shuttle is irreversible transfer e- only to u without pumping protons yield 2atp synthesis. When we are oxidising we move e- around. Hand over e- in tca cycle in etc. Multiple complex system sit within a membrane. Taking reduced e- feeding to chain driving protons movement release. Protein complex need to give and take e- Nadh mobile carriers bring e- to etc. Haems carry o2 iron not change much in redox stage.
