PHRM4011 Lecture Notes - Lecture 1: Nortriptyline, Omeprazole, Adverse Drug Reaction
Document Summary
Prolong life: cholesterol lowering drugs in cardiovascular disease, one meta-analysis of 17,617 patients found that the reduction in the risk of major coronary events (30%), cardiovascular mortality (27%), and all-cause mortality (23%) Improve symptoms - quality of life levodopa in parkinson"s disease, Omeprazole in reflux disease: save lives penicillin in infection, insulin in diabetes. Risk factors for mrps: patient-related living alone (people also had a history of cognitive, hearing or vision impairment) adherence issues, show signs of adverse drug reactions, unexpected responses to medicines, medicine-related. Medicines with a high dose or narrow therapeutic index: critical thinking: thinking rationally/reasonably and to find what to do, gather info, analyse, evaluate, decision making reason. Trimethoprim 300mg d for 3 days, 7 days for males. Adherence intermittent treatment adoption episodic eg asthma factors: intentional. Unintentional dexterity/physical issues, price, forget intentional/unintentional eg price ie don"t save up if not worth it. Socioeconomic low income, low health literacy, age cognitive impairment, gender.