PHRM4011 Lecture Notes - Lecture 3: Oxazepam, Postmarketing Surveillance, Digoxin
Document Summary
Digoxin serum target for hf 0. 5-0. 8mcg/l, af 0. 5-2mcg/l. For crcl60ml/min halve dose: crcl30-60ml/min 62. 5mcg-250, crcl10-30 62. 5-125, crcl<10 62. 5 d or alternate days. Monitor trough level (min 6hr post dose/just before dose) Se nausea, anorexia, confusion, bradycardia, blurred vision. Rate control <90-100bpm effervescent tablets = salt so taking nearly 4g of salt. Medical ethics is concerned with moral values, code of conduct. Medical ethics is a moral compass to guide in complex and confusing situations. Beneficence do good, use evidence-based medicines: rct limitations single condition, homogenous trial group, ironically elderly use medicines most but are excluded from trials. Autonomy respect rights of self determination: their own preference/choice of medication outcome, pill burden, complicated by patient incompetence, discrepent views between patient/family, absence of detailed medical advice in advanced care directives. Med reources: veteran"s mates, nps, australian prescriber, amh, amh aged care booklet organized by condition, emims product info available from tga but organised, etg, up-to-date.
