PHRM4012 Lecture Notes - Lecture 12: Microbiological Culture, Nonsteroidal Anti-Inflammatory Drug, Quinolone
25 Jul 2018
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Do not treat asymptomatic uti treat symptomatic/pregnant uti. Trimethoprim 300mg d for 3 days (bacteriostatic) inhibit bacterial folate synthesis. Drugs that cause hyperkalaemia acei, nsaids, potassium-sparing diuretics reduce dose crcl 10-30, contraindicated crcl <10. Cephalexin 500mg bd for 5 days reduce dose in crcl <20. Se nausea, vomiting, diarrhea, rash, blood dyscrasia. Nitrofurantoin 100mg bd for 5 days inhibits bacterial dna/rna/proteins. See dr if tingling, weakness in limbs. If resistant norfloxacin 400mg bd for 3 days. Do not take within 2hrs of antacids/calcium/iron/minerals. Can cause dizziness careful while driving/alcohol. Pregnant bacterial culture in 1-2 weeks after tx: cephalexin 500mg bd for 5 days reduce dose in crcl <20ml/min. Se nausea, vomiting, diarrhea, rash, blood dyscrasia: nitrofurantoin 400mg bd for 5 days inhibit bacterial rna/dna/proteins. Se nausea, vomiting, headache, vertigo, polyneuropathy, brown urine/lenses. Take with food better absorption, decrease stomach upset. Tell dr if tingly/weak in limbs: amoxicillin/clavulanic acid 800/125mg bd for 5 days.
