EXSS3050 Lecture Notes - Lecture 9: Atherosclerosis, Low-Density Lipoprotein, Homocysteine
22 Aug 2018
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2: intermittent claudication: pain w/ exercise, relieved by rest in pvd. & legs if lower at legs this may identify if there is an issue. Pvd: lecture 7b: pvd is asymptomatic so many people go undiagnosed (~50%) therefore need risk factor modification. Important to check feet for pvd in order to diagnose & confirm w/ bp readings. Pvd risk factors: causes are vitamin b12, b6 and folic acid deficiency. If you supplement with these: homocysteine: (cid:1371) >(cid:883)5umol/l leads to (cid:1371) risk of endothelial injury (cid:1372) vascular inflammation (cid:1372) atherogensesis, lipoprotein a: (cid:1371) >(cid:884)(cid:882)(cid:882)mg/dl possibly affects coagulation. Function is mostly unknown: nicotinic acid and aspirin reduce levels you can aid the breakdown of homocysteine, interleukin-6: pro-inflammatury. More research is needed: fibrinogen: high levels associated with cvd. More research is needed: fibrinogen, c-reactive protein: elevated basal levels increase risk of cvd. More research is needed: cystatin c: a biomarker of kidney function.
