PHAR3816 Lecture Notes - Lecture 3: Peripheral Artery Disease, Coronary Artery Disease, Cerebrovascular Disease
22 Jul 2018
School
Department
Course
Professor
Document Summary
Common causes of death: morbidity, reduced qol. E. g. large vessels in diabetes also has microvascular. E. g. nephrotoxicity, retinopathy associate with significant decrease in qol and economic burden. Review individual history such as acute events, smoking etc. Fasting glucose level is important in diabetes and monitoring renal function- crcl in assessing increased risk of vascular disease. Daly time lost due to fatal and non-fatal events i. e. time lost due to premature death + years of healthy life lost due to disability. Mrfit: correlation between cholesterol levels and chd death. Non-linear key paper is the relationship between lipid levels to chd mortality. Cholesterol: essential component of cell membranes, bile acid & precursor of steroid hormones. Triglycerides: broken down to free fatty acids & glycerol & taken up by adipose tissue & muscle (energy source) Chylomicron remnants- formed when chylomicrons are broken down: very low density lipoproteins (vldl-c) Low density lipoproteins (ldl-c: high density lipoproteins (hdl-c) increases level.
