PHAR3816 Lecture Notes - Lecture 5: Reverse Cholesterol Transport, Peptic Ulcer, Niacin
22 Jul 2018
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Document Summary
Coronary heart disease - atherosclerosis and lipid management. Level a evidence for use: data show that intake of epa and dha can significantly decrease serum tgs along with plasma concentration of certain lipoproteins. 4 1000mg capsules of omega-3 fatty acids containing 465mg of. Epa and 375mg of dha per capsule can effectively decrease tg levels by up to 45% and is generally well tolerated. Adverse effects: gi upset, increased ldl in some people. Interactions: additive effects with anti-hypertensives, high dose fish oils have an anti-platelet effect at >10g per day. It has been suggested that niacin has the potential to regress atherosclerosis because of its ability to affect reverse cholesterol transport out of vessel walls. Main adverse effects: which may be reduced by taking with evening meal, taking aspirin just before niacin. Flushing in up to 50% of individuals: niacin should be avoided by people who have gout, diabetes, low blood pressure or a history of peptic ulcer disease.
