PHAR3818 Lecture Notes - Lecture 22: Local Anesthetic, General Anaesthesia, Isoflurane
23 Jul 2018
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Document Summary
General anaesthesia is the loss of consciousness and responsiveness to pain. They work on the cns, unlike local anaesthetics, which act on the sensory neurons. They can be administered intravenously, and used to induce anaesthesia, and inhalationally, which is used to maintain it. In stage 2, respiration and heart rate is irregular, vomiting can occur, so try to avoid stage 2 and go straight from 1 to 3. They have a fast onset of action to avoid side effects and avoid stage 2. The duration is also shorter so the patient can recover quicker. Oil-gas partition coefficient: measure of lipid solubility as it crosses the bbb very easily. Gave rise to lipid theory of how inhaled general anaesthetics work: nowadays it is believed they work on receptor target e. g. halothane and isoflurane on gabaa receptors. The stronger the green colour, the higher the stimulation. The stronger the pink colour, the higher the inhibition.
