PHAR3819 Lecture Notes - Lecture 5: Diabetes Mellitus Type 2, Natural Killer Cell, Rheumatoid Arthritis
23 Jul 2018
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Document Summary
Inflammation involves a continual ubiquitous cascade of complex signaling pathways and processes that are initiated and maintained by the immune system, affecting virtually all aspects of physiology, including energy metabolism it can be defined as acute or chronic. Systemic inflammation has been recognized as an essential component in the pathogenesis of a variety of conditions: The metabolic low-grade chronic inflammation seen in obesity is driven by cytokine release from stromal and resident immune cells of metabolically active tissues in response to excess nutrients and energy. This source of inflammation is recognized as a principal contributor to metabolic disease. Adipocyte expansion and increased adipocyte-associated macrophages amplify the secretion of cytokines and adipokines that possess inflammatory and diabetogenic properties inducing insulin resistance type 2 diabetes. Innate and adaptive immunity processes within the joint in rheumatoid arthritis. According to treatment protocol, e. g. for cd20-positive b cell non-hodgkin lymphoma, chronic lymphocytic leukemia.
