PCOL3012 Lecture Notes - Lecture 5: Thioether, Alpha Helix, Hydrogen Bond
Document Summary
Structure of drug targets: proteins: transporter, receptors and enzymes, amino acids, proteins, structure. Majority of drug targets are proteins: receptors, enzymes, transporters. Structural proteins- most structural proteins (collagen, keratin) are not drug targets. One structural protein that is a useful drug target is tubulin- anticancer agents. Receptors enzymes and transporters: the most important drug targets. The recognition between a receptor and a neurotransmitter is a form of chemical communication. Therefore, we should be able to modulate (alter) how this process works by using chemicals or drugs. Introduce compounds as antagonists- compounds that bind to the receptor but do not activate it and prevent the natural messenger from binding. Introduce compounds as agonists- compounds that mimic the natural messenger and activate the receptor. What(cid:859)s the differe(cid:374)(cid:272)e (cid:271)et(cid:449)ee(cid:374) a re(cid:272)eptor, tra(cid:374)sporter a(cid:374)d a(cid:374) e(cid:374)zy(cid:373)e: all protein-based biomolecules, all involve recognition-based interactions with low-molecular weight compounds.
