CAM202 Lecture Notes - Lecture 4: Orthostatic Hypotension, Afferent Arterioles, Efferent Arteriole
11 Oct 2018
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Document Summary
Captopril, ramipril, quinapril, enalpril, fosinopril, perindopril, lisinopril, trandolapril. Antifibrotic effects- slowed progression of renal disease. The fall in protein excretion may be associated with decreased serum lipid levels, reducing risk of systemic atherosclerosis and slowed progression of renal disease. Direct improvement in the permselective properties of the glomerulus, independent of changes in glomerular haemodynamics. Clinical use: oedema associated with heart failure, renal impairment, nephrotic syndrome, and hepatic cirrhosis. Adverse effects: electrolyte imbalances- hypokalaemia, hyponatraemia, hypochloraemia, dehydration, dizziness, orthostatic hypotension, hyperuricaemia. Inactivate na+/cl- symporter in the distal tubule loss of na+, cl-, and water in urine. Increased delivery of na+ to the collecting tubule also causes a corresponding increase in k+excretion: also cause vasodilation by unknown mechanisms, secreted into the lumen of the pct, where the flow to the site of action. Clinical use: oedema associated with heart failure, nephrogenic diabetes insipidus, hepatic cirrhosis. Adverse effects: electrolyte imbalances- hypokalaemia, hyponatraemia, postural hypotension, dizziness, hyperglycaemia, hyperuricaemia.
