PHAR2220 Lecture 17: Endocrine System Notes

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25 May 2018
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"!The!endocrine!system!regulates!many!of!the!body’s!activities:!
o!Growth!
o!Reproduction!
o!Adaptation!to!stress!
o!Metabolic!activity!
o!Availability!of!glucose!!
o!Circulatory!volume!
o!Ca2+!homeostasis!
"!These!effects!are!produces!by!chemical!messengers,!called!
endocrine!hormones,!which!are!secreted!from!endocrine!glands!
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"!Released!from!the!cells!of!an!endocrine!gland!into!the!bloodstream!to!induce!a!specific!
physiological!effect!on!cells!of!another!organ!(target!organ)!!
"!E.g.!
!
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T3,!T4!
Thyroid!
All!tissues!
Increase!metabolic!
activity!
Insulin"like!growth!
factors!(L1)!
Liver!
All!tissues!
Growth!
Cortisol!(L2)!
Adrenals!
Many!tissues!
Adaptation!to!stress!
Testosterone/oestrogens!
(L3)!
Testes/ovaries!
Reproductive!organs,!
CNS!
Reproduction!
Aldosterone!
Adrenals!
Kidneys!
Circulatory!volume!
Parathyroid!hormone!
Parathyroid!
Kidneys,!bone!
Ca2+!homeostasis!
Insulin!
Pancreas!
All,!especially!liver,!
muscle!and!fat!
Availability!of!fuel!
(glucose)!to!cells!
!
"!Endocrine!hormones!produce!effects!that!are!critical!to!the!effective!functioning!of!our!bodies!–!
thus,!their!release!is!highly!regulated!(unregulated!release!can!lead!to!serious!disease)!
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Control!of!Endocrine!Hormone!Release:!
!
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T3,!T4!
Thyroid!
Increase!metabolic!
activity!
YES!
Insulin"like!growth!
factors!(L1)!
Liver!
Growth!
YES!
Cortisol!(L2)!
Adrenals!
Adaptation!to!stress!
YES!
Testosterone/oestrogens!
(L3)!
Testes/ovaries!
Reproduction!
YES!
Aldosterone!
Adrenals!
Circulatory!volume!
NO!–!Renin,!
Angiotensin!II!
Parathyroid!hormone!
Parathyroid!
Ca2+!homeostasis!
NO!–!Blood!Ca2+!levels!
Insulin!
Pancreas!
Availability!of!fuel!
(glucose)!to!cells!
NO!–!Blood!glucose!
levels!
!
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1.!Stimulated!
!
!
!
!
!
!
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Negative!Feedback!Control!of!HPA!Axis:!
2.!Inhibited!
!
!
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Releasing!Hormones:!
"!Synthesized!by!hypothalamic!nerves!
"!Released!in!response!to!CNS!signals!(1)!
"!Travel!via!bloodstream!(portal!venous!system)!(2)!and!stimulate!
receptors!in!anterior!pituitary!gland!!
!
Trophic!Hormones:!
"!Synthesized!by!pituitary!gland!(3)!
"!Released!by!releasing!hormone!
"!Travel!via!bloodstream!and!stimulates!receptors!on!target!
endocrine!gland!
!
!
!
!
!
!
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