CHEM 2513 Lecture Notes - Lecture 23: Williamson Ether Synthesis, Epoxide, Racemic Mixture
1 Dec 2018
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Npal name cant hydrogen bond to each other so their bp arent that high . Alcohols a ethers can - bond to water. Previously , we learned these methods to make alcohols. No rearrangements , but inversion of stereo them. Better than halides because are very stable and very weakly. 3 resonance structures stabilized p pyridine base used weak to deprotonate also can. Turn alcohol into alkoxide usings . base then perform sn2. Having more than one functional and brings is by using unwanted results protecting groups once easily the be is rxn. , silyl groups deprotected using ions group common creates competing rxns way to protect them using silyl chloride. 0 epoxide: syn addition all in one step common. :(mcpba ) loss of carboxylic acid us gives trans gives meso us conformation the racemic mixture: epoxides are reactive because of their ring string so they perform both , acid catalysed : an acid diluted.
