BIOL 235 Lecture Notes - Lecture 9: Hypoventilation, Cachexia, Interleukin 10
Document Summary
Copd is preventable, but underdiagnosed; affects at least 700,00 adults, approx. 4th leading cause of death in females, 5th in males. Higher prevalence in women except for the > 75 years age group. The above mortality results may be lower than in reality because pneumonia or congestive heart failure are put down as the cause of death as opposed to copd. Copd is the 6th leading cause of death worldwide. Accounts for the highest rate of hospital admissions amongst major chronic illnesses in canada. Hospitalization - on average is 10 days & costs ,000 per person. Total costs come up to 1. 5 billion dollars per year in canada alone. 15-20% smokers will be dx (diagnosed) with copd; 80-90% dx with copd have a hx (history) of smoking. Is toxic to cells in lungs & impairs mechanisms responsible for lung tissue repair. Genetic susceptibilities - polymorphisms of genes that code for tnf (tumor necrosis factor), surfactant, proteases and antiproteases.
