SCIE 1P51 Lecture : Pharmaceuticals

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Series of meetings to come up with code for practice of patients being tested. Protection of participants: respect for persons: treatment of person as autonomous, beneficence: issue regarding potential conflict between good of society vs. individual, justice: treatment of all fairly and all equally share benefits and risks. Historically women were excluded if of reproductive age (ages 18-45) Fear of harm to potential unborn child. Sources of pharmaceuticals: before mid-19th century natural sources, plants, micro-organisms anti-biotics, animals. All new pharmaceuticals/food additives must be fully evaluated before they are approved for use. Amount of chemical that kills exactly half of the population of animals. Ld50 is expressed as weight of substance per unit weight of test animal. Levels determined in this phase used for next level of testing. Continuous exposure for at least 90 days. Time course of a to e, dose response of a to e. Method of administration: orally, subcutaneously, intraperitoneally, intravenously.

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