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Lecture

Overall prnciples of complement

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Department
Biology
Course Code
BIOL 1103
Professor
Tamy Superle

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Description
Outline of Lecture 07 Complement I. Overall principles of complement 1) Two overall phases: enzymatic and lytic (pore forming) 2) Split products are formed during complement cascade, both products are biologically active 3) There are three ways to activate C’, and all converge at C3 II. There are three ways to activate C’ 1) Classical Pathway Activated by C1 binding to IgM or IgG which are bound to Ag Specifically, C1q portion binds two Fc regions, then C1r/C1s cleaves C4 C4b reacts fast, e.g. covalently binds bacterial cell surface whereas C4a remains soluble C4b binds C2, C1s cleaves C2, results in C4b2a complex (the C3 convertase) 2) Mannose Binding Lectin MBL is homologous to C1, but does not require antibody to activate Like C1, MBL cleaves C2 and C4 to create the C3 convertase 3) Alternative Pathway C3 can “tickover”, i.e. spontaneously covalently bind surfaces In appropriate environment, C3 complexes with B; B is cleaved by D C3bBb complex recruits properdin (P); this is a C3 convertase III. Further down the complement cascade A) What C3 does C3a is anaphylactic: causes mast cells and basophils to release histamine C3b collects
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