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BIOL 1104 (30)
Lecture

Control of ECF Volume II (Blood Volume)

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Department
Biology
Course
BIOL 1104
Professor
Tamy Superle
Semester
Fall

Description
Control of ECF Volume II I. Control of Blood Plasma Volume a. Typical 70kg person has 5L blood (3L plasma, 2L hematocrit) b. Glomerulotubular balance—a change in GFR (flow) => a proportional change in Na reabsorption so that the fraction reabsorbed is constant i. Blood volume is normally constant over a wide range ii. ↑Na intake => ↑ ECF volume iii. ↑Na intake => ↑ mean arterial blood pressure (but blood volume = const) iv. [Na] is main determinant of ECF volume & [K] of ICF volume c. Volume/Pressure Sensors i. Extra-renal sensors 1. arterial baroreceptors 2. intrathoracic low pressure receptors ii. Renal sensors 1. juxtaglomerular apparatus
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