BIOL 2107 Lecture Notes - Lecture 1: Reactive Oxygen Species, Penicillin, Methyltransferase

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Forward mutation changes wild-type allele to a different allele e. g. a+ ---->a or b+ ----->b. Reverse mutation (reversion) changes a mutant allele back to wild type e. g. a---->a+ or b---->b+ Prof: a mutation is alteration to dna structure and there are 2 different types. Forward mutation has a much higher chance of occuring than reverse mutation. different type of mutations. Substitution replacement of a base by another base: transition purine replaced by another purine, or pyrimidine replaced by another pyrimidine (prof: there are two types: the purines and pyrimidines. Adenine (a) and guanine (g) are both purines, while cytosine (c) and thymine (t) are pyrimidines. If a purine changes to a purine, the substitution mutation is considered a transition. Likewise, if a pyrimidine changes into a pyrimidine, the substitution mutation is also a transition): transversion purine replaced by a pyrimidine, or pyrimidine replaced by a purine (prof: transversion is the opposite of transition substitution).

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