FYSM 1310 Lecture Notes - Lecture 8: Morris Water Navigation Task, Sentience, Outline Of Object Recognition
2 Feb 2017
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Document Summary
For drug trails (to obtain an index of safety dosages) Researchers are able to easily control the variables. They can also use in vitro models (cell & tissue cultures) Characteristics needed in animals used for ad research. Must be predictive, and translatable to humans. Object recognition box with 2 toys, the next day one toy is changed. Genetically modified fruit flies, made to express beta secretase/amyloid: useful for testing a variety of drugs. These mice are based on genetic mutation found in familiar ad. Express human mutant app @ high levels as well as amyloid plaques. These mice are able to how researchers that; Amyloid plaques are age dependent and form as expected in the hippocampus. These mice develop plaques faster and are triple transgenic. Although, these are not very practical animals to use. This is why researches use induced animal models. How to researchers induce ad in animal models. Use of drugs: cholinergic models, amyloid inject.
