NEUR 1201 Lecture Notes - Lecture 13: Vascular Dementia, Sleep Disorder, Extrapyramidal System
11 Jun 2020
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In 1901, alois alzheimer observed a patient at the frankfurt asylum named mrs. Auguste deter: the 51-year-old patient had strange behavioral symptoms, including a loss of short-term memory. Written and spoken language may become simpler and more concrete: as the disease progresses, symptoms become more severe. Language skills decline, leading to problems communicating: noticeable deficits in long-term memory begin to appear (cannot recognize family members), ___affect__ and ___emotion__ begin to be affected. Individuals may become irritable, aggressive, or prone to emotional outbursts. B_ plaques: these are clusters of misfolded, defective proteins that accumulate in and around neurons, amyloid- plaques are neurotoxic . Every treatment currently in use can, at best, temporarily mitigate some deficits: acetylcholinesterase inhibitors: Increases levels of acetylcholine by inhibiting the enzyme that normally breaks it down. __aricept_ : nmda antagonists, dying neurons haphazardly dump excess amounts of glutamate into the brain.
