NEUR 1203 Lecture Notes - Lecture 10: Pars Compacta, Substantia Nigra, Pars Reticulata
24 Jun 2020
School
Department
Course
Professor
Document Summary
Parkinson disease: what is pd, pd is a progressive, neurodegenerative, adult-onset movement disorder originally described by dr. james parkinson in 1817 in his work an essay on the shaking palsy. Legs freeze up when walking, shuffling gait: postural instability: problems with balance; can lead to falls, before these symptoms occur app. Loss of daergic neurons in the substantia nigra pars compacta (snpc: these neurons project to the striatum. Loss of these projections leads to dysfunction of basal ganglia, influencing voluntary movement: motor symptoms arise mostly due to this dysfunctional circuit. Much still unclear (including -synuclein"s role in healthy brain) but most people with pd have them. Lbs present in other disorders, too, and even in healthy individuals; buchman et al. (2012) found that out of 744 healthy patients, 17% had lbs without fulfilling. It"s still unclear, but probably a combination: pd pathology: molecular. Tumor necrosis factor alpha is toxic to embryonic mesencephalic dopamine neurons.
