NEUR 2001 Lecture Notes - Lecture 12: Random Assignment, Internal Validity, Interrupted Time Series
2 Jan 2019
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Lecture 12 quasi-experimental vs. nonexperimental research strategies. Note: in both these types of strategies, we compare pre-existing independent variables at different points in time. Some control; compare to another group that acts as the control. No control at all, you observe the way it is. When the independent variable is a participant/subject variable or a time-related variable: participant var. Age, weight, genetics, etc: time-related var pre/post event, event at different times. There is an inability to randomly assign participants to groups. Transgenic knock-out (deletion/inactivation of a gene) or knock-in mice to investigate the independent variable. Compensatory changes produced in an organism that is developing a functioning without that gene. Littermate controls choose a control mouse (mouse without the transgene) from the same litter as your transgenic mouse: helps to eliminate effects on the mouse, prior to birth or before wearing/separation from mother. Alternatives: conditional knockout inactivate gene in specific brain region, temporal conditional knockout inactivate gene only at certain times.
