NEUR 2200 Lecture Notes - Lecture 8: Metabotropic Glutamate Receptor, Nitric Oxide, Axon Terminal
8 Apr 2016
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Neur 2200: lecture 8 neuropharmacology part 2. Some are inhibitory at one locaion and excitatory at another. More than one neurotransmiter may be acive at a single synapse. No simple one-to-one relaionship between a single neurotransmiter and a single behavior. The chemical must be synthesized in the neuron or otherwise be present in it. When the neuron is acive, the chemical must be released and produce a response in a some target. The same response must be obtained when the chemical is experimentally placed on the target. A mechanism must exist for removing the chemical from its site of acion ater its work is done. Three classes of neurotransmiters: small-molecule transmiters, pepide transmiters, transmiter gases, small-molecule transmiters. Synthesized from dietary nutrients and packaged ready for use in axon terminals. Examples: acetylcholine (ach, amines: dopamine (da), norepinephrine (ne), epinephrine (ep), serotonin (5-ht, amino acids: glutamate (glu), gamma-aminobutyric acid (gaba), glycine (gly) Tyrosine is precursor amino acid for dopamine, ne and e.
