NEUR 3200 Lecture Notes - Lecture 7: Ionotropic Glutamate Receptor, Biogenic Amine, Choline Acetyltransferase
14 Jul 2017
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Document Summary
Neuronal nicotinic ach receptors can be made out of only alpha and beta subunits. But, there have been found 10 alpha and 4 beta subunits, and you can have a functional receptor, with only alpha, 1 alpha and multiple beta etc. the differences in the composition lead to differences in condunctance, how fast ion channels open/close and to the ratio of calcium and sodium passing through. All this leads to difference in function: recognize the relative abundance of glutamate as a neurotransmitter in the brain. Most abundant, released at more than half synapses in the brain: understand the general functions of glutaminase, vesicular glutamate transporters (vglut), excitatory amino acid transporters (eaat) Nmda -> this allows a lot of ca in the cell, which can then act as a second messenger. Nmda-> glutamate binds, glycine binds and depolarization of postsynaptic membrane: be familiar with which neurotransmitters are typically inhibitory.
