NEUR 3401 Lecture Notes - Lecture 9: Chemokine, Microglia, Myelin
21 Feb 2020
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Tbecome activated by viral or an infectious antigen that mimics cns antigen. Aintegrins which help t cells get into brain chemokines specialize in immune cell traffic. Antigen presenting cells apc will present myelin ones from periphery microglia finish this macrophage release super oxide oj. Cd8 ind of t cells can get into brain to produce grandzyme perform seen most attack myelin in the late stages of disease. Tha believed to be made in your gut and are educated by microbiome they go into the brain to attack myelin paper there is an imbalance in microbiome disbyosis inversely correlated to prevotella good anti inflammatory. Ebu by iself will not give ms but its ebv other environmental stuff. Ebv can infect activate clonally expand b lymph persist as a letent infection whn these cells they become reactivated by something can cause ms. Inf cytokines il io occurs when anti immunoregulatory mech such as treg cells become activated after some point they stop.
