NEUR 3403 Lecture Notes - Lecture 2: Model Organism, Autoimmune Disease, Controllability

• School: Carleton University
• Department: Neuroscience
• Course: NEUR 3403
• Professor: Hymie Anisman

Document Summary

Chemical changes, brain is telling you something you did is not going well. By doing this study several times, i will get the same result. Whether of (cid:374)ot you"re (cid:373)easuri(cid:374)g what you thi(cid:374)k you"re (cid:373)easuri(cid:374)g. Mice were favoured due to all the genetic mutations which could be done. Curing cancer in animals probably have no effect in humans. Similarity: symptoms seen in humans should also be seen in the animal (ie. anhedonia should be seen in both, physiology, similar responses. Autism example: what would you look at in animal model, we do(cid:374)"t k(cid:374)ow e(cid:374)ough a(cid:271)out sy(cid:373)pto(cid:373)s of autis(cid:373, cant necessarily measure what you would in humans, in animals as well. Most predi(cid:272)ta(cid:271)le thi(cid:374)g a(cid:271)out stressors is that they"re u(cid:374)predi(cid:272)ta(cid:271)le. Two-hit hypothesis: first hit could be stressor, infection or genetic thing, this puts you into a new more vulnerable state, second or third hit will break you. Daily hassles: cumulatively may have an effect.