NEUR 4306 Lecture Notes - Lecture 4: Microdialysis, Research Question, Basal Ganglia
16 Jul 2020
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Bal: balanced mixture of amino acids: 2. Aptd: same as bal, except lacked phenylalanine and tyrosine (precursor to da and. 5ht) leads to depletion of brain da: 3. Aptd + dopa: reverses above; given two doses of l-dopa prior to testing (bypasses. In this case, incentive sensitization motivation circuitry: the circuitry involved in the cues and more sensitive, are responding more and more, only require small stimulation. Evidence: dopamine release to ventral striatum correlates with locomotor sensitization (kalivas. Criticism of the incentive sensitization theory: used non contingent injections, too much emphasis on stimulants, animal models: see generalization of sensitization to stimuli different to drug (e. g. , food + cocaine) Incentive salience: learning and dopmaien, proposed by berry everett, addiction is a learning disorder. It is maladaptive learning: drugs promote learning of strong automatized" s-r habits compulsivity, theory: da release in the basal ganglia can lead tgo compulsive behaviour (everitt, Evidence for da in compulsive behaviour: methods, microdialysis experiment.
