NEUR 4306 Lecture Notes - Lecture 5: Insomnia, Delirium Tremens, Allostasis
16 Jul 2020
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Lecture 5: neuroanatomy and neurobiology of withdrawal and craving. Recall: koob and volkow: addiction involves 3 stages, binge/intoxication, withdrawal/negative affect, preoccupation & anticipation, withdrawal and negative affect, stage marked by irritability, malaise (sick), dysphoria; loss of motivation for natural rewards. Opiate withdrawal syndrome: rats, wet dog shakes. Like dog whose come out of the water: ptosis (droopy eyes, teeth chattering. Lacrimation tearing: ear wipes, monkeys, salivation, emesis, vomiting, tachycardia, sporadic heart rate, piloerection, hair stands up, negative affective state seen in animals , anhedonia, dysphoria, anxiety. Drug withdrawal is marked by a negative affective state evidence: 1. Rats will avoid an environment paired with opiate withdrawal (conditioned place. Aversion; cpa): pair one side of cpp chamber with withdrawal state, mucha et al. , cpa. Increased withdrawal behavior correlates with avoidance of the paired environment with withdrawal: 2. Drug withdrawal increases icss thresholds: across many different drugs, overall does not matter which drug, any drug withdrawal elevates icss.
