PHIL 3009 Lecture Notes - Lecture 1: Transdermal Patch, Nicotine Gum, Sublingual Administration
14 Jul 2015
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How drugs are handled by the body l1. Pharmacokinetics in greek: pharmacon means drug and kinetikos means putting in motion, the study of time dependency is the time course of a particular drug"s actions: absorption distribution. 4. elimination: bioavailability generally decreases (due to incomplete absorption and first-pass metabolism) or may vary from patient to patient. Bioavailability must be considered when calculating dosages for non-intravenous routes of administration. Enteral administration (oral: must be g. i. resistant liquid vs. tablet/capsule passive diffusion lipid solubility. Enteral administration (rectal) delivered in suppository used in restricted conditions. Parenteral administration (inhalation) rapid exchange between lung and blood rapid delivery to brain used for anesthetic gases. Parentral administration (mucous membrane) administered through nose/mouth absorbed through mucosal membrane directly into bloodstream sublingual administration includes: cocaine, nitroglycerine, nicotine gum. Parentral administration (transdermal patch) provides continuous, controlled release absorbed through epidermis directly into bloodstream nicotine (anti-smoking), fentanyl (chronic pain), estrogen (birth control)
