PSYC 2307 Lecture Notes - Lecture 4: Radial Glial Cell, Subventricular Zone, Dentate Gyrus
19 Jan 2017
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Document Summary
Begins in 3rd week after conception and continues postnatally. More neurons and more synapses at birth than ever again. Brain reaches 90% of adult volume by age 6. Neural tube forms between e19 and e29 (embryonic day = e#) Closure of central regions of the neural tube at e22 which continue in rostral and caudal directions. Primary vesicles evident by e28 (prosencephalon, mesencephalon, rhombencephalon. Secondary vesicles evident by e49 (prosencephalon differentiates to telencephalon and. Diencephalon while the rhombencephalon differentiates into the metencephalon and. Seven stages of early neural development: neurogenesis / gliogenesis, neuronal migration, neuronal differentiation, dendrite and axon growth, formation of synapses, neuron death/synaptic pruning, formation of myelin. Begins with segregation of the neural plate from the ectoderm. The neural plate folds to form the neural tube (the progenitor of the cns) and neural crest. Later cns neurogenesis involves proliferation of ventricular neural stem cells, differentiation, migration, and lamination of the developing cns.
