PSYC 3403 Lecture Notes - Lecture 9: Dorsal Root Ganglion, Opioid Antagonist, Chronic Pain
19 Feb 2014
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Two classifications: acute pain, chronic pain. Acute pain: caused by soft tissue damage. Chronic pain: linked with long-term illness or disease, may have no apparent cause (no obvious wound, can trigger other issues, difficult to assess and diagnose, long term. Nociception: refers to the system that carries signals of damage and pain to the brain, nociceptive neurons have cell bodies in the dorsal root ganglia, can detect mechanical, thermal (ex: hot water), and chemical (ex: acid) stimuli. Nociception transmission: bidirectional axons synapse in dorsal horn of the spinal cord, signal continues to brain where its processed (signal crosses horn and up to brain) Natural: from the resin of poppy seeds, morphine, codeine, thebaine. Semi-synthetic: created from natural opioids (but have been modified, heroin, oxycodone, hydromorphone. Fully synthetic: derived in a lab, methadone, fentanyl. Derived from the resin of the opium poppy (papaver somniferum, sleep-bringing poppy ) Us buys 80% of its supply from india and turkey.
