PSYC 441 Lecture Notes - Lecture 11: Mesolimbic Pathway, Serotonin Receptor Agonist, Basal Ganglia
10 Nov 2017
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Lecture 11 neurotransmitter systems in sz: the dopamine system, recall, nucleus (2 nucleus = nuclei): A bunch of cell bodies in white matter (e. g. , hippocampus): mesolimbocortical pathway, vta projects to: Hippocampus: mesostriatal pathway, substantia nigra projects to: Cortex (frontal and parietal) via the basal ganglia (i. e. this is the link with the mesolimbocortical pathway, they both influence the cortex: frontal cortex, has an inhibitory projection to vta (i. e. works to regulate da; upregulation from. Anesthetic used as a sedative to treat severe agitation (positive symptoms) in sz. Chlorpromazine was found to block da receptors: Upregulation for the basal to the frontal cortex: antipsychotics are effective because they block da in the vta, ho(cid:449) the (cid:894)si(cid:373)ple(cid:895) da h(cid:455)pothesis does(cid:374)"t (cid:449)ork, even when psychotic symptoms are improved, people with sz remain impaired: They began to identify frontal lobe deficits in sz: These deficits sometimes appear before symptom onset, in first- degree relatives.
