BIOC 2300 Lecture Notes - Lecture 15: Signal Transduction, Endocrine System, Protein Kinase A

35 views14 pages

oliveminnow466

27 Feb 2019

School

Dalhousie University

Department

Biochem & Molecular Biology

Course

BIOC 2300

Professor

David Byers

For unlimited access to Class Notes, a Class+ subscription is required.

Document Summary

Bioc 2300 lecture 15 february 27, 2019 signal transduction. Classification of signal transduction: signal transduction (or cell signaling) can be classified by, physiological system (ex. neural, , nature and origin of extracellular signal (see the right, type of receptor involved. Body has to recognize things and get extracellular responses across the plasma membrane. Nature and origin of the signal itself we have contact dependent signalling, where the signalling + target cells have to be in contact with eachother. A tissue can secrete a factor to call for more blood vessels. Synaptic between nerve cells working with neurotransmitters. Endocrine the more typical signalling; global in nature; epinephrine/adrenaline released in blood stream to effect a lot of cells. Transduction: also: nuclear receptors (ex. estrogen receptor) A cell has a plasma membrane that separates it from its environment. There are many steps involved, but they allow for the amplification of signals. A little bit of g-protein activates a lot of kinase.

Related Questions

QUESTION 1

Which of the following is an example of an extracellular signal molecule?

	a.	IP₃
	b.	cAMP
	c.	Insulin
	d.	Diacylglycerol

2 points

QUESTION 2

Nuclear hormone receptors _____

	a.	Bind to water soluble ligands
	b.	Activate second messengers
	c.	Regulate transcription in response to ligand binding
	d.	Are normally located on the plasma membrane

2 points

QUESTION 3

Which of the following does not occur when a receptor tyrosine kinase is bound by ligand?

	a.	Phosphorylation of the RTK
	b.	Cytoplasmic proteins bind the phosphorylated RTK
	c.	Dimerization of the RTK
	d.	The RTK binds to DNA to regulate transcription

2 points

QUESTION 4

Which of these is a logical signal-transduction pathway?

	a.	An intracellular receptor activates phospholipase C, which cleaves a membrane protein to form IP₃, which then activates the opening of an ER channel protein, which releases cyclic AMP into the cytoplasm, where it binds to an intracellular enzyme that carries out a response.
	b.	A G-protein-linked receptor activates G protein, which activates phospholipase C, which cleaves a membrane lipid to form IP₃, which binds to a calcium channel on the ER, which opens to release calcium ions into the cytoplasm, which bind to an intracellular enzyme that carries out a response.
	c.	An ion-channel receptor opens, allowing a steroid hormone to enter the cell; the steroid hormone then activates protein kinases that convert GTP to GDP, which binds to an intracellular enzyme that carries out a response.
	d.	A tyrosine-kinase receptor activates adenylyl cyclase, which activates phospholipase C, which converts ATP into cyclic AMP, which binds to an intracellular enzyme that carries out a response.

2 points

QUESTION 5

Which of the following is an example of signal amplification?

	a.	activation of an enzyme molecule
	b.	activation of a specific gene by a growth factor
	c.	Breakdown of many cAMP molecules
	d.	activation of 100 molecules by a single signal binding event

2 points

QUESTION 6

Consider a signal transduction pathway that utilizes cAMP as a second messenger to activate PKA (Protein Kinase A). Which of the following situations will result in the cellular response?

		The G protein releases GDP and binds to GTP
		The target protein (adenylyl cyclase) is inactive
		The regulatory subunits of PKA (Protein Kinase A) are bound to the catalytic subunits
		The appropriate G protein is bound to GDP

2 points

QUESTION 7

Which of the following is found in only some signal transduction pathways? [In other words, which is not found in all signal transduction pathways?]

		Receptor protein
		Extracellular signal molecule
		Intracellular signaling molecule
		Cellular response
		Effector protein

2 points

QUESTION 8

The enzyme that specifically catalyzes the conversion of ATP to cAMP is:

		Adenylyl phosphatase
		Adenylyl kinase
		Adenylyl dehydrogenase
		Adenylyl cyclase

2 points

QUESTION 9

If an animal cell suddenly lost the ability to produce GTP, what might happen to its signaling system?

		It would use ATP instead of GTP to activate and inactivate the G protein on the cytoplasmic side of the plasma membrane.
		It would not be able to activate and inactivate the G protein on the cytoplasmic side of the plasma membrane.
		It would employ a transduction pathway directly from an external messenger.
		It would be able to carry out reception and transduction but would not be able to respond to a signal.

2 points

QUESTION 10

A hormone signal is sent from the brain to other parts of the body via the bloodstream. Why do only certain cells respond to this signal?

		Hormones do not last long enough in the bloodstream to stimulate a cellular response
		Only cells that have a specific transcription factor gene will be able to respond to the signal
		Only cells in the immediate vicinity of the cell sending the signal will respond
		Only cells that have a receptor for the specific signal will be able to respond to it

cerisehedgehog846

BIOC 2300 Lecture Notes - Lecture 15: Signal Transduction, Endocrine System, Protein Kinase A

Document Summary

Get access

Related Documents

BIOC 2300 Lecture Notes - Lecture 14: Signal Transduction, Protein Kinase A, G Protein–Coupled Receptor

BSC 283 Lecture Notes - Lecture 5: Ibuprofen, Cyclooxygenase, Aspirin

BIOC 4580 Study Guide - Final Guide: Tubulin, Transmembrane Protein, Lipid Raft

Related Questions