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Lecture 4

BIOC 3300 Lecture Notes - Lecture 4: Phosphoenolpyruvate Carboxykinase, Glycogen Phosphorylase, Pyruvate Carboxylase


Department
Biochem & Molecular Biology
Course Code
BIOC 3300
Professor
Mc Leod Roger
Lecture
4

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1. 1,6-glycosidic linkages:
2. Allosteric control on phosphorylase a & b:
3. Bond involved in mobilization of glycogen?: Phosphorolysis
of α-1,4-glycosidic linkages of the glycogen polymer
4. Branching Enzyme:
Branching enzyme is amylo-(1,4-1,6)-transglycosylase.
It transfers a fragment of 6-7 glucose units from a length of at
least 11 units to an interior glucose in α1,6 linkage
5. The change of [F26BP] on glycolysis and gluconeogenesis:
Figure 15-17b
6. The control of glycogen phosphorylase activity.:
7. Conversion of pyruvate to phosphoenolpyruvate: - requires
energy input and proceeds in two steps.
- addition of CO2 to pyruvate to produce oxaloacetate using ATP
by pyruvate carboxylase.
- reaction occurs in the mitochondrial matrix (must be
transported to cytosol for remaining steps).
- phosphorylation and decarboxylation of oxaloacetate by PEP
carboxykinase (PEPCK) in presence of GTP.
- investment of 2 high energy phosphates.
8. Debranching enzyme:
Required to mobilize at branchpoints.
9. Dephosphorylation of fructose-1,6-bisphosphate: - catalysed
by fructose-1,6-bisphosphatase.
- not coupled to ATP generation, Pi is released.
- a major site of regulation of gluconeogenesis.
10. Dephosphorylation of glucose-6-phosphate: - catalysed by
glucose-6-phosphatase in ER.
- not coupled to ATP generation, Pi is released.
11. Enzymes in mobilization of glycogen:
Lec 4 - Glycogen Metabolism and Gluconeogenesis
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12. factors affect activities of PFK-1 and FBPase-1?:
Figure 15-15
13. Features of Enzymes in Gluconeogenesis: In gluconeogenesis,
the reverse reactions are catalysed by enzyme systems and
pathways that are thermodynamically favorable for glucose
synthesis; requires energy input.
14. Fructose-2,6-bisphosphate:
Fructose-2,6-bisphosphate is an allosteric activator of
phosphofructokinase and an inhibitor of fructose
bisphosphatase.
15. Gluconeogenesis:
the metabolic process by which organisms produce sugars
(namely glucose) for catabolic reactions from non-carbohydrate
precursors.
16. gluconeogenesis:
17. Glucose-6-phosphatase: Only in the liver.
Generate glucose from glucose-6-P for transport in the blood
18. Glycogen:
19. glycogenesis:
20. glycogenin:
Serve as "primers" for
glycogen synthase to extend
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