BIOL-2126EL Lecture Notes - Lecture 14: Intermediate Filament, Nuclear Lamina, Tubulin

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Allows the cell to maintain shape, organize components, interact with environment. Built from intermediate filaments (fibrous proteins), microtubules (globular tubulins), and actin filaments (glubular actin) Have great strength as they allow cells to withstand mechanical stress like when the cell is. Toughest and most durable of all cytoskeletal. Creates the nuclear lamina in the nuclear envelop stretched. Many long strands are twisted together like a rope to provide strength. Strands are made of intermediate filament proteins which are fibrous subunits with an elongated rod: rod domain consists of a- helical region. Forms dimer when wrapped with another: forms tetramer when wrapped with another dimer. Prominent in cells that are subject to much mechanical stress. Distribute applied forces so membranes do not tear. Grouped into four classes: abundant in epithelial cells and skin cells, keratin filaments. Saturday, november 7, 2015: vimentin and related filaments. Connective tissue, muscle cells, and glial cells: neurofilaments. The cabling of the filament allows the.

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