BIOL 200 Lecture Notes - Lecture 4: Lac Operon, Lac Repressor, Sigma Factor
7 Jun 2016
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Must properly position the active site to be on top of +1 to initiate transcription. Not what you need to respond to changes in the environment. Unicellular vs multicellular: single celled organisms: genes are regulated to adjust to changes in the nutritional and physical environment. Cell usually produces only the proteins required for survival and proliferation under the particular environmental conditions it experiences: multicellular organism: genes are regulated to ensure coordination during embryonic development and tissue differentiation (for formation of organs) You have an assembly complex which will recruit rna pol 2 and ensure you express that gene in high enough levels. Operons: in prokaryotes about 50% genes are organized in operons, operons are a series of genes that all have similar function. Most commonly sigma 70: sigma factors are a component that regulate rna activity. Biol200: protein that recognizes a dna sequence. Has a motif within itself that recognizes dna sequence.
